Hi Danny,
Blasphemy to you perhaps, but if you were to use the Neo10 in a sealed enclosure for midrange, what volume would you use and how would you dampen it? Also would you use a baffle wide enough so as to avoid BSC down to its high-pass corner or would you opt for as narrow as possible for better imaging? In both cases, what sort of sensitivity can be expected from one unit around the crossover frequency (200-300)?
Been there done that and crossed it to a Neo 3 pdr.
The amount of air space is not critical as it is never going to play below 150Hz. The important thing is that it is not a shallow box. If the air space is too small then it will lift the response at 500hz and cause it to roll off too sharply. I'd go 10 to 12" deep for the best response. And you want to make the baffle as narrow as possible. Adding any width disrupts the response above 800Hz. Play with the deep and watch the response. You can use the air space to adjust the knee in the lower range. That is where it loads and where it starts to drop.
And 92.5db is what I got with it.
And you can cross in the 200Hz to 300Hz range with no problem.
And last question (!) since there is no Xmax spec available for the Neo10, if you high-pass at say 250Hz using LR4, how much peak power would you think they safely could take before they shriiiieeeek....? 
You won't need a high order crossover at all. The acoustic drop will be pretty steep in a sealed box, and a first order is all that you need to protect it. With just a first order filter on it you can play the crap out of it.
And when you are ready for the Neo 10's let me know. I do keep them in stock.