Desertpilot, I feel your pain. Any treatment in my room is limited by several factors. Hoped REW would held identify the worst problems and then hoped would be possible to apply treatment. Measured, measured, measured with REW. Moved speakers, angled speakers, added diffusion, added absorption, EQ'd per REW analysis, set speakers on vibration dampers, added spikes. Finally arrived at listening position pretty smooth FR according to REW.
After months of fiddling, had to have achieved audio nirvana? For a while believed there was no room for improvement, so the sound quality had to be great. The more I listened, the less I liked. Could not totally get rid of a 50 HZ boom, had to just be room mode. Definitely more detail, but Midrange and Highs tended to be harsh and edgy. After weeks of trying to convince myself good measurements had to mean good sound, started tweaking based on ears only. After a couple hours of EQ adjustment, attenuating from 2.5K up and DSP adjustment to the subs everything sounded much better. No loss of detail and in particular vocals much smoother with no screechiness. Solid, clean, articulate bass.
Will eventually measure with REW, but no desire to immediately know what I did. REW likely helped along the way to identify big problems. However, it also proved my ears do not like a flat frequency response.