6rs,,, it's a definte yes depending on the USB cable. Some make a little difference, others can transform your system, and I'm making this statement strictly on what I've found using 3 different USB cables
in my system. I am presently auditioning Locus Design's Axis USB cable and I don't see any way I can part with it after witnessing what this single cable has done for my Trend's UD-10.1 USB transport. I've also heard god things about Ridge Street Audio Design's USB cable.

I was on the fence also after replacing a Belkin Gold for a Kimber USB cable and didn't really notice any startling improvement. That has all changed for me within the last week as the Axis cable gets some miles on it. You will pay thru the a$$ for this cable but if you're not willing to make the sacrifice, whatevcer you do
don't audition it. I say this with total honesty simply from what I've witnessed this last weekend from a simple Trend's unit. Those with better USB transporters/DAC's I would imagine will even be more impressed from the Axis. I plan on posting a thread on this subject after the Axis is totally broken in and I've done comparisons with the other cables. But I know my system pretty well and I'm doing things with it now in the higher volume region that would have been unbearable last week.
For me, in my system, to say the Locus Design Axis USB cable has transformed my system would not be an understatement,, just pretty much dead on.

Cheers,
Robin