I think it can depend on a what kind of audiophile you are, if you are a person who has a system goal and you are able to reach personal satisfaction by selecting the right gear to get what you want, and then tweak it to get the best out of it then that is always a very good thing as far as amplifires are concerned.
There are some people who wouldn't entertain anything other than aTube amp in there system so for them the right tube amp is the end of the road.
if you are an audiophile with ‘DIY tendencies’ then things change a little, the goal of finding your perfect system is still there but the desire to keep on building new gear doesn't go away and it can become another hobby in itself, once you have built your first amplifier or speaker the satisfaction you get out of having built it yourself is a great feeling especially when it competes with (or beats) the commercial competition for less money.
For some people DIY hi fi holds no interest at all and they would much rather just go and buy something (nothing wrong with that either

)
Because I am an audiophile who enjoys building a bit of DIY gear my system is always evolving. I now have several different amplifiers to choose from ranging from class A, B and D most of which I built myself. (with valve monoblocks on the way aa )
So I guess I will never reach the end of the road because although I am satisfied with my system as it stands it keeps on changing evolving and expanding, in fact I have now built so much stuff I have 2 systems to play with. It does make the whole thing more complicated because I now have a choice of gear to choose from, they all satisfy me in their different ways and it is great fun mixing and matching components.
At the end of the day although I enjoy building some DIY hi fi I do it all for a higher purpose THE LOVE OF MUSIC
The Rolling Stones may have said "I can't get no satisfaction" but I get several different kinds of satisfaction with my collection of home made gear
