I have two brands of big-ticket "boutique" speaker wire at home. One is approximately 20 times more expensive than the other. One is a 6 gauge equivalent, the other 18 gauge. One is about half silver, the other is OF stranded copper. There is a 10ft run to the left speaker, a 20ft run to the right speaker, so series R of the wire does come into play.
The two wires sound distinctly different, one being considerably more transparent and detailed than the other. I won't bother to identify which is which. Suffice it to say I listen with the wire I find closer to the sound of live music.
My experience does not support the conclusions of the article cited in this thread, or the stance of its author towards wire and interconnects. Indeed after 30 years I am inclined to contradict virtually everything he says.
It remains for the audiophile to determine what sounds "best" to him, and what expenditure is required to achieve that best sound. I believe that with training and experience (I have 30 years in as an audio engineer), many audiophiles can "hear a difference" and correctly identify an improvement over a sideways or backwards move in sound quality, due to wires, interconnects, room treatment, sources, amplification, or speaker systems.