I don't see any advantage for audio? I guess if you use a USB 3.0 DAC that could be a minor upgrade.
They finally separated USB from Ethernet. Advantage here will mostly be in data throughput through each since they no longer have to share the same data pipeline, but this could improve usb audio out from the pi. I never used usb audio from a pi, only used I2S audio.
But otherwise, advantages are for video and speed, not for audio.