What if someone drops something into the port? (Makes me think of those little games where you have to get the ball bearing through the maze.)
That was the only significant drawback I could think of, and the OP asked for "any sonic quality reason" not to use a top port, though I suppose there are things one could drop down the port that would affect sound quality.
Once I designed a tall skinny custom speaker where the only dimension with enough length for the ports was the vertical plane. I used one upfiring port and one downfiring port, both with flares, and lined up so that if you dropped something down the top port, it would come out the bottom port. That's probably not practical in this case.