Keep it simple, at least, at first. Match your speakers to your room and your required listening levels, then choose an amp which matches with your speakers. Some of today's integrated amps offer much better value, and equal performance, to a separate pre amp/amp combo.
Speakers first, source second, amplification third. And stay away from tweaks until you get the basic set up sounding good. Also, speaker placement is everything, do not even bother with high end stuff if you are unwilling to place speakers where they need to be to sound their best (away from the walls for most speakers).