There are also claims that there is no audible difference between 16/44.1 and 320kbps or VBR MP3, while in fact there are, and significant ones, so do not pay attention to it, such statements are usually made by people with poor hearing or badly informed or simply ignorant to the whole concept of music reproduction.
In terms of FLAC versa WAV, it can be audible as well, doing real time decompression of FLAC does have a significant cost in additional CPU cycles and can be very audible on some systems due to increased jitter. This is why people go to extreme lengths to minimize CPU/memory/power consumption in custom built cost no object PC based digital sources.
Finally, regardless of some claims, there is no PC based digital source that can match performance of top player as long as we compare reproduction of 16/44.1, simply because with PC based source you pay the penalty of sending the signal to an external DAC for conversion over many more components in the path that inevitably increase jitter, and there are no such things as jitter immune DACs, again contrary to some claims.
It all depends on how far you want to take it, if you want absolutely the best reproduction of 16/44.1 then top end dedicated CD players are unbeatable. But PC based sources bring the ability to play higher resolution signal and that leaves CD players behind.