If the sub is above a basement or crawlspace you can brace the floor with a post or column below the sub's location. Mass will have minimal effect at sub frequencies. Suspension/damping is the next best, but you may lose some transient accuracy / impact if spring is too loose like inner tube, but it will isolate well.
I'd like to try these, but they are not shipped to US, have to ask a friend in Europe to help.
http://www.sonicdesign.se/sdfeet.htmlUnrelated to vibration but still a big improvement in clarity (which I assume is why you want isolation?) is to raise the sub up off the floor on a speaker stand.
Rich