Yes.
I just bought a used pair of Manley Neo Classics 250s, that when I turned it on, a power tube blew a d took out the fuse and a resistor. The amp was bricked until I could order a new resistor and replace it.
However, if both tubes are glowing hot orange, i would have to assume that maybe something else is wrong with the amp and that one particular tube section is misfiring.
A red-hot tube means that the tube is getting too much voltage; if you can bias tube I don't think it should be glowing red; unless somethif is wrong with the pot and it's not working.