You might check out Mozy Pro if you want offsite backup for your NAS.
If you don't mind the command line, then to backup/sync folders between computers I use "rsync".
rsync -avr /path/to/NAS/Mount /path/to/NAS/Backup
For the unix, linux and mac osx users that is built in. For the windows user you can install cygwin. The first backup will be long and any additional backups would be new and modified files. There are options to do checksums vs timestamp on the copy along with preserving previous copys on the backup location.