It does give up some control and low end extension verses the transmission line design, but there are no issues with using it in a ported enclosure. The other drawback is that it is an inch wider so you wind up with some disruption to the response from added surface reflections.
I did do a design using one of those boxes last year. It was a 2.5 way design using the Neo 3 pdr and 2 M-165X woofers. The box was sealed. It sounded great but it was still 4db down in sensitivity from the N3 and didn't play as low, so I saw no sense in going further with it.