Input, rectifier, driver, output etc - what role do the various tubes play? I have 6 tubes worth a thousand dollars surrounding a $28 rectifier, are rectifiers not as important or do they have less bearing on the sound? 
Can a great tube sound less than stellar with other great tubes, i.e. is there such a thing as tube synergy? 
Alot depends upon the design used if the tubes will sound less than stellar when combined.
I love tubes, but tube rectifiers require smaller input capacitor filters without arcing, and if a choke is used, either as input or elsewhere in the filtering system, the power supply becomes more reactive. The last thing one wants is more reactance in the power supply, if we wish accurate fidelity. If a tube rectifier makes a sonic difference, then the choke, where ever it is located and with its high reactance, will make a sonic difference.
For instance, using a 40uf capacitor, the capacitive reactances at 20hz and 10khz are:
20hz = 199 ohms
10khz = .4 ohms
Let's check the inductive reactance of a 10 henry choke.
20hz = 1256 ohms reactance
10khz = 628,000 ohms reactance
Again, if a tube rectifier makes a sonic difference, then the choke, where ever it is located and with its high reactance, will make a sonic difference.
There are so many different designs, but I will attempt to give generalities.
Usually the input tube is designed for voltage/signal gain. The driver tube may have voltage/signal gain, or have a gain of less than one. It depends upon the application the output tube uses. If grid current is drawn over a portion of the audio/signal cycle, then the driver tube is either cathode out (for low impedance), or plate out and uses a stepdown interstage transformer to handle the grid current/crossover from high to low input impedance of the grid.
Of course the output tube and associated parts are used to "supply power" to the speaker/load.
Hope these crude examples help.
Cheers.