Hey, good luck with the build, sounds ambitious. Roxul is a brand name for about 25 different rock wool products. The two major products used for audio applications are Rockboard and Safe'nSound. Rockboard is a stiffer product that can be shaped and molded, and has higher sound absorption co-efficients below 250Hz than the same thickness of Safe'nSound, which is the floppy sound insulation product I now think you're referring to. But yes, both products will work very well as interior insulation of speaker systems. I'm not too fond of foam products for sound insulation, they can be okay for high frequencies, but are very uneven across the full audio spectrum. If dense enough, foam can be used to good effect as tweeter surrounds, but not much else. Let us know how the build progresses.