I done a lot of A/B tests looking at how different software processes and how using different I/O methods affect the sound. Here are a few thoughts relevant to the thread.
The mouse and keyboard functionality have to run somehow. As Dave said all process tax the system and seem to have a minute affect on the sound. If you have a good system, you can here these minute sound degradations.
With the Mouse/Keyboard you have 3 main options.
1) USB - Not good, if you have a USB DAC or if your music is on an external USB Drive
2) Bluetooth - Not bad. Although you get a little better sound with Bluetooth disable, the degradation is subtle
3) Use Screen Sharing and access the Mini via your network connection. Most of us already have the network enabled for Internet Radio or Pandora. Enabling the Screen Sharing function has very minimal sound impact.
I use option 3 in my system since I usually have my laptop open anyway when I listen to music. I use it to read, email, look stuff up, etc. You could also use an itouch etc this way.
Another poster seemed to disbelieve that a music server needs all the system resources. It is hard to believe, after all, a music server uses very little system resources. The problem is that time slicing of memory and CPU slightly affects timing of the music delivery (sounds like the concept jitter, eh). When you first run a MacMini or other music server, it probably will sound very good. The music application has plenty of memory and CPU, so life (and sound) is good.
But, if you turn off unneeded background process, the sound becomes fuller, less hash and haze, cymbals sound tighter, you hear an over all improvement. By reducing the time slicing, the timing of the music is more accurate and has a quieter noise floor.
I have gone through my Mac and turned off every process I don't need. I've uninstalled all non-music programs I can find. Almost everything I turned off made an audible difference. The collective impact of all the software mods is substantial.
I know it sound crazy, so I suggest folks just try it for yourself. If you have a resolving system you will hear improvement.
Darrell