I'll restate what I said earlier: Try it. Most Audio Physic speakers are a relatively easy 4 ohm load, and a good tube amp, such as the Ayon, should be good with them. It will NOT affect tube life having 4 ohm speakers. I have used low impedance speakers with tubes for years.
Try the combo. If the bass is tight and not under-damped, the high treble sounds natural, and you can get enough volume in YOUR room, then I say go for it. If anything sounds "off" - then don't.
While I agree that Bryston make good gear, they do not sound anything like tubes. On the Odyssey Stratos idea - I have owned that amp and it is bright - it has its place in a system with warm, laid back speakers or with a tube preamp but with Audio Physic speakers it'll tear your ears out.