This could be an interesting project, but would be rather more difficult than you might realize.
There are a couple major problems
1) the 6th amp channel is ONLY used when decoding 6.1 surround formats. the multichannel analog input DOES NOT include a way to route sound to this amp. So, using analog inputs you really only get 5 amp channels, plus volume control over the sub. This would mean that if you were using the analog inputs, you'd still need another stereo amp to get you up to 12 channels.
2) The analog inputs are really not that good. I'm certain there are many other 'conventional' HT receivers with 5.1 or 6.1 analog inputs that would be better suited to this if you were intending to do this off-the-shelf.
However, if you wanted to make a serious project out of it, using a digital xover that was modified to feed a couple XR45 (also modified, of course) directly via I2S lines, then you might really have something interesting. I think this could in fact be a killer system, but you'd pay for it with the effort and time involved in the mods.