It has a SATA interface, so it should be a simple plug and play installation. If you have 2 SATA controllers on your motherboard, I would connect it to the same set of SATA headers that your current optical drive is connected to.
Vista doesn't have native Blu-ray burning capability, so you would either install a burning program that may have come with the unit, a freeware burning program such as ImgBurn, or one of many third-party burning programs.
If you intend to playback Blu-ray movies, Vista also has no native software for that, so you would need to install some kind of Blu-ray movie playback software. Your video card would also need to be HDCP compliant (and most likely is).
Steve