In general, keep the interconnect cables between the preamp and the power amp as short as practical.
If you must use long interconnects, make sure they have a full braid shield and are as low a capacitance per foot as possible.
In general, amplifiers are load driving devices and the speaker wires are a negligible load in comparison to the speakers themselves (as long as the speaker wires are not woven designs that trade off inductance for high capacitance. Avoid those as they will change the sound and possibly damage your equipment.
Preamplifiers in general do not have anywhere near the load driving capability as a power amp, and a long interconnect cable can roll off highs, pick up lots of noise, and generate a capacitive load the preamp cannot drive without distortion.
Use common sense about this, not "audiophlake sense".

Regarding monoblock amplifiers, this essentially doubles the amplifier price with usually no musical value increase in proportion. All AVA amplifier can be run as bridged mono amplifiers at more than 3 times normal single channel power. The circuits to do this are now available as an option built into our new AvaStar preamplifier.
Best regards,
Frank