In general it is safe to run just one channel of a big solid state amplifier.
I would suggest that, if you can, located and remove the main + and - internal power supply fuses for the unused channel. This will allow the full power supply to drive just one channel.
However, be very sure you know the way your amplifier works. Some have separate supply feeds for the audio boards and output transistors. If this is the case, the fuses should remain in place.
Finally, the best thing to do is ask the manufacturer or dealer of your amplifier if leaving one channel disconnected is OK for that particular unit.
Best regards,
Frank Van Alstine