I'd say as a general rule, if your mains are fairly full range - say, flat to 40-50Hz - then a crossover in the 40-60Hz range is easiest to integrate and tends to sound better, but gives little dynamic advantage.
If you can manage to cross around 80Hz, then a significant advantage is gained with regards power handling and dynamic range, but you are pushing it if you are working with a single mono sub, especially if you listen much to orchestral music where stereo bass is important and mono bass below 90Hz is clearly audible and inferior.
If you have the luxury of stereo subs then you can cross as high as 100-150Hz and gain big power advantage, but integration is usually difficult at those high frequencies.
Easiest integration I have experienced was at 40Hz between my stereo 10" Hsu subs and either my Tannoy Ardens and my SP Tech Timepieces, flat down to 40Hz and 30Hz, respectively. The TPs, especially, were easy to match.