Sorry, I forgot about the second half of your questions. It's always best to replace with a two matched quads. I don't see any need for a matched octet. I don't recommend it, but you can get away with replacing them one at a time if each tube is individually biasable...though I believe the other tubes can wear faster if you do this. If they bias in pairs or are if the amp is self-biasing forget about it! Get matched quads.