Yes, you can do it the way you described, but I suggest it is not a very good idea.
In general, a power amplifier is designed to drive loads, a preamplifier, within very specific limits, is not designed to drive loads.
A 25 foot long interconnect cable will represent a rather large capacitive load to the preamp. The capacitance per foot of the cable times the number of feet. This will do two bad things. First as this "capacitor" gets bigger, it will tend to roll off the very high frequencies. The amount of roll off will depend upon the value of the capacitor into the input impedance of the amplifier. For this reason, all other things being equal, keep the interconnects as short as practical and as low capacitance as possible.
The second bad thing is that the capacitive load has to be charged and discharged ever duty cycle of playback. This requires current. The current requirements to charge the capacitor may exceed the output current capability of your preamp's line stage. When the demand for current exceeds what is available, the distortion goes towards 100 percent. Our Insight and Ultra preamps will do well with this, the pure tube T8 not as well as small signal tubes alone have poor current drive capability and we are doing the best we can here with the relatively high output current 6N1P tubes.
Actually there is a third bad thing. A capacitive load tends to slow down the feedback loop and cause the feedback to arrive late. This can been seen with simple square wave tests - - as the capacitive load increases, the leading edge overshoots. If the load is too great, the unit can go into full bore oscillation. Again, extremely unlikely with AVA equipment which is designed to drive nasty capacitive loads, but the larger the capacitive load, the more the output will deviate from the input, and there is a name for that - - - distortion.
Finally the amplifier is a load driving device. 25 feet of 14 gauge standard two conductor speaker wire is a negligible load for an amplifier as compared to the loudspeaker itself.
So it seems to make sense to let the amplifier drive most of the load, an easy to drive speaker wire, and remove as much load as possible from the preamp which has nowhere near the load driving capability as a well designed power amplifier.
That is the reason I think your scheme is not a good idea.
Best regards,
Frank Van Alstine
P.S. One other thought. The very low level signal to the amplifier is much more sensitive to noise and RFI pickup than the high level signal to the speakers (especially if you twist the speaker wires 3-4 turns per foot). Your idea will maximize noise pickup possibilities.