I think applying veneer on both sides of the MDF does little to prevent the cabinet from separating. The air that is sealed inside the cabinet when it was built is unlikely would cause any problem, assuming the factory was environmentally controlled.
Moisture could still get in from the edge of the wood even after you put veneer on both sides, unless you put veneer around the edges too.
Workmanship of the carpenter, and the environment the cabinet is in contribute more to how long the cabinet will last.
I have many pairs of vintage speakers that are 30 to 40 years old and the cabinets are still fine, except for one speaker from a pair of AR 4x, but the 2" gap was there when I bought it.
The Dynaco A25XL is a ported cabinet design. Air can move freely inside and out, bringing in humidity (and it's changes) on a regular basis. My cabinet maker uses double sided MDF all the time on his projects. This is how he builds them and seeing his work, I'll not question his methods nor his construction techniques.
BTW, I have owned several well cared for speakers that eventually came apart at the seams that at the time, I thought were built well. One was a JBL-L100, the other a Marantz Imperial 7.
The effects of humidity change vary from zone to zone. Here in Minnesota the winter can easily put the humidity in the house around 20-25%, getting towards desert conditions. In the summer, it can be 100%.
I guess my point is if you DIYer's don't want to use double faced MDF, don't. If you think the need was not required for my cabinets, fine. It cost me really nothing extra, and I have relied on the talents and experience of a master builder. I don't have that big of an ego to tell an expert how to do his job.
Wayner