Actually both the 350EXR and 550EXR use three pairs of power mos-fets per channel, not two pair. Both are safe into very low impedance loads.
The 550 has a larger, higher current and higher voltage power transformer. In addition, parts in the power supply and audio circuits are rated for higher power, higher voltage use with the bigger amplifier. Otherwise the two amplifiers are identical in design and sonic performance, within the limits of the 350's power rating (about 200 watts per channel).
Frank Van Alstine