One of the most telling experiences I had was with a tube amp designer and his own gear. He put his 150 watt per channel stereo tube amp on a pair of Quad 57s in a reasonably sized room and it sounded not so great. Later, in a much larger room, a room I would have suspected too large for Quads, he used the same amp(s) but configured as mono blocks. Great sound. Then we listened to an 8 watt 300b Airtight amp. Great sound again.
We then put an Ayre AX 7 on a Bozak monster. Ugh, what happened here, flat, flat, flat. However, the stereo tube amp sounded great on the Bozaks.