If you're looking for the best, and the best will only do, then LEAP speaker design suite is clear all around most complete system available. but be prepared to pay...and pay...and pay... for it.
Now, if you're like the rest of us, and there is no such thing as cost-no-object, then other applications like Winspeakerz and BassBox Pro (with XOver Pro) are good choices, and can be had for a couple hundred bucks.
There is also the availability of a lot of Freeware, which of course is often objectionable. However, I've been using WinISD Pro recently, and have had good luck with it. It already comes loaded with about 150 drivers in it's database, and you can add your own with the T/S parameters. It does ported, sealed, multi-driver (up to 10), but only really focuses on the bass/mid-bass. It doesn't incorporate upper freq drivers into it's design. But hey, it's free.
