I have a PrimaLuna amp. It came with KT88's which was very competent in reproducing all the upper registry in comparison to the EL34's I had in my older amp. After 7 months a tube failed. In addition to replacing the bad tube, on a recommendation from Upscale Audio, I bought a set ot KT77's.Right out of the box they threw a MUCH bigger soundstage and had a liquid midrange like EL34's. I am still running those as the sound is seductive. So, I know the sound of 3 tube types in my gear. EL34, magic midrange, KT77, vast soundstage with the magic midrange. KT88, power and better definition of the upper registers. The KT88's reproduce the sound of a metal instrument like a triangle amazingly.
Yes, changing tubes to another type does have a big effect. I have also read that buying better tubes of the same sort will have an effect but I have never tried that.