I am not an expert, but ...
If you go totally off the grid, then there will be no ground loop hum. But being totally off the grid may not be practical.
If you were to get the Isabella (with DAC) as preamp, Macbook as source, Signature 30.2 as amplifier and an active subwoofer, then you'll be okay. This is because the Isabella and 30.2 are both off the grid, and the Macbook has a non-grounded power adapter. In this situation, you have only one grounded device, the powered subwoofer, and hence no ground loop.
But if you add a CDP to the picture and you go coaxial digital or analog RCAs to the Isabella, then you have a potential ground loop problem between the CDP and the powered subwoofer. If you use optical instead, then there's no electrical connection, and hence no ground loop.
If you didn't have the active subwoofer, then CDP over coaxial digital or analog RCAs would be no problem as this is now the only AC powered device, and hence, once again, no ground loop.
If you do have ground loop hum, I think the best way to fix it is to have an electrician come in fix the faulty ground. All wires entering a structure are supposed to be grounded through the same ground source. This may very well be cheaper than buying all new equipment.
If you've got everything plugged into the same wall outlet, and you've still got hum, then there's something funny going on. Aside from ground faults, I've found that the cable (television, satellite) connection is often the culprit here. Do you have a dedicated 2-channel system, or do you have it doing double duty as a HT system? Or perhaps a DVD player which is connected to your television and your stereo?
Anyway, like I said, I'm not an expert. Just piecing together some things I've read, ground loop problems I've encountered before, etc. Totally happy to be utterly wrong. =)
