Observe all safety precaution, and following safety procedure. So we have been told at work. However, many times we don't have the luxury to work on live circuit with another person. The job has to be done.
At home, how many time that live circuit has to be fixed when no one else around, just you.
I was repairing a radar beacon at work, old stuff, component level repair, and I was alone. At the output section of the unit there were four power tubes that put out 5000 killing volts of RF. The safety cover for the tubes had been lost (it was a cannibalized unit with many parts missing, my job was to make it work).
I was paying close attention to that dangerous area at the time knowing what I was up against. Then I tried to connect my RG-59 to the test port, I was holding the cable steadily, and still inches away from the power tubes. All of sudden I saw a big ball of orange light jumping at my hand holding the cable. Next thing I knew, I was frantically trying to pull my hand away from the light, it seemed like eternity, but I am sure it was only seconds.
I pulled myself out, my finger was burned with great pain, and I could smell the burn, but I survived 5000 volts.
The current has to go through your heart to kill you, touching a live circuit with one hand, if the current doesn't go through your heart, you'd just get a nasty shock. Therefore that 500Vdc in a tube amp doesn't really scare me, because I don't think that low of a voltage will jump at you, remember, it's only 500Vdc.
Folks, I am not downplaying safety, be very careful, don't work on live circuit if you can help it, electricity can kill. I have been lucky.