This is a loaded question. First, one must have the fully fleshed out schematic in order to opine what any compromises might be, or what kind of circuit we are even dealing with, or one must have the ability and tools to do various measurements to determine what the best is.
You mentioned you didn't have the time to experiment empirically, so then the only way to "optimize" is to take a bunch of measurements with different values. Otherwise there is no optimization at all, neither empirical nor measured. You can change the value of this FB resistor and see what happens, whether you like it or not, but that isn't an optimization.
If we have a schematic, then one can makes some edjumacated guesses about what might the appropriate amount of FB be based on the experiences of others. Many/most of the commercial offerings follow a handful of 50's designs (williamson, mullard, etc) and based on the tubes chosen there is a lot of data already out there, so there is safe guesses, which might be good enough for you.
I guess what I am trying to say, is there is a difference between real measured/analyzed optimizing of a circuit and ad hoc changing based on rules of thumb.