If you have a lot of dust, here's a neat trick that relies on the fact you can use the Snapshot feature of History to paint w/ filters.
Zoom in on your image and find the most common size spot. Go to Noise>Dust and Scratches and select the minimum pixel radius and maximum threshold radius that wipes out the dust spot but retains the texture (noise and/or grain structure) of the image. Don't worry right now the filter has probably obliterated the details of your image. (the D&S filter could also be called the 'edge destroyer') BTW the filter does a poor job w/ scratches despite it's name.
Now, and you must follow this sequence. Go to your History palette and click New Snapshot. Then immediately hit Undo (Cmnd+Z on a Mac
The image will now appear as before you did anything.
Now choose the History Brush (Y). Set the source for the HB by clicking the EYEBALL next to the new Snapshot (NOT the snapshot itself) Choose an appropriate brush size and hardness and just go and paint away that dust, making sure to steer clear of edge details. If you have areas w/ relatively little detail, this method can be very fast.
You can do the Snapshot/History Brush trick w/ any filter! Paint in selective blurs, sharpening, whatever.
Cool huh?