Just my opinion, but DOA3 isn't a zit on the smooth curvaceous, er... on the ass of Soul Caliber! At least not the original SC; I haven't seen a demo yet of the new one that was playable. But obviously YMMV.
As for the mouse, I'm too much of a console guy, too. I just can't get used to the mouse for gaming, not even for Diablo. Of course if I'd cut my teeth on PC gaming it'd be a different story. But I essentially never play any games on the PC whatsoever, no in years.