bj,
in the first place a U-frame will be useful to have better control over the rear bass output. If you can´t place your OB or H-frame far enough from the front wall, a U-frame should be helpful. As shown in the diagram, regarding radiation to the front a U-frame of certain depth is 6 dB more efficient than a H-frame of the same size.
Because the U-frame has less directivity than a dipole, in theory the U frame should excite more room modes than a dipole. But if a U-frame gives you more freedom of placement in the room, this could easily be more helpful to control room modes than the radiation pattern.