Hi Ghamel,
This is a vexed question. Will a different driver work well with the AKSonics crossover? Heck, I dunno...... You'd have to try it, it's all a gamble.

The crossover will certainly work, no question, but it won't be optimized for the 8545 (or 8546) driver, and careful tweaking could well be required.
Speaker design comes back to crossover design. Generally speaking, that's where the magic is. If you change the drivers, the myriad of compromises incorporated into the crossover all shift, and there lies the problem.
I spoke to Ron, and this was his comment.
He is well aware of the Scanspeak driver, and emphasizes that this driver is substantially different to the M18WO-08-09 Vifa. He has designed with them for his clients, and says that they are priced high very carefully to cynically attract the DIYer whose labor input building the speaker is then absorbed by the higher price driver. He believes the Scanspeak drivers are only marginally better than the quality Vifa and Peerless offerings, and dismisses them out of hand as TOO EXPENSIVE!!! Resonance on the Scanspeak 8545 is nominally 26Hz, compared to 35Hz; VAS is 72 litres compared to 28.5 litres; Mechanical Q (a vital statistic which largely contributes to the slam and placement of low notes) is 2.5 compared to 6.7, and cost is $US131 compared to $US64.
In closing, and my thanks to Jens for his input on this bass driver, I'd say this, all checked and passed with Ron

:
1. Three ways cover the range better, but mandate use of a band pass, which is a low pass and a high pass in series, and which CAN have a dislocating effect on the phase (and hence the image) of the music signal.
2. Two ways are a bit stretched, so you tend towards a smaller woofer, say up to about 170mm, which goes up to around 2,500Hz, the usual crossover point for a two way. But a smaller driver compromises low bass - you just can't have it all.....
3. Even a 5" driver will comfortably go down to 100Hz, so you really need only a sub to cover the range 30-100Hz, and this is eminently doable with quite steep low pass filters because psychoacoustically it appears the ear is not to peturbed with phase dislocations in this range (it certainly doesn't disturb imaging, and in any case sub bass is non-directional).
4. The logical outcome of the foregoing is to employ a sub woofer for augmentation, run the two way full range with its simple high/low pass crossover, and use steep electronic and mechanical crossovers to augment the bass with a sub-woofer. In any event this will give you much more bass power than moving to the Scanspeak driver which has an almost identical diaphragm size anyway.
Generally, #4 has been my choice. However, with the AKSonics the deep bass is actually very good, and I never bothered with my isobaric 2 x 12" sub any more. I find I don't crave low bass these days, any more than I want to sit behind a 6 litre V8 auto engine. (Must be getting old.......

)
So, on balance, it does seem to me that a sub is really all you need, but YMMV, and likely does, and that's fine. But be assured that whatever decision you take, it will always be swings and bloody roundabouts!!! You just can't get away from the engineering!
Cheers,
Hugh