Assuming cost-no-object and that I actually had ample enough money to spend on such frivolity and the room to put it in, well, I suppose there are nearly infinite possibilities, but here's one:
Marten Design Supremes driven by Lam ML-3s with Jorma Prime speaker cables and Valhalla or Elrod PCs. Main source: Boulder modded SB2 in custom Brazillian Rosewood enclosure with 10 coats of hand-rubbed C-37 lack, Audio Note silver foil PIO output caps and with captive Stealth Indra ICs, and of course the Ultimate PSU, and full Summit cabling. And what the hell, let's throw in an Audio Note M-10 pre and a Brinkmann Balance TT with Lyra Titan cart. I guess we're talking about something like $350k here. Insanity

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Hell, if I could find a nice vintage Mac amp to drive my Adagios and a nice sub to complement them, that's about as good as I could want in my small house, along with what I already have.
Or... you could call the good folks at Acapella and have them custom design and build in a 16' bass horn into your wall then go for one of their top-of-the-line speakers and recreate the LSO in your room. You're probably talking over a million by the time that's done. Where does it end?
Truth be told, even if I had the money, the time, the room, etc. I can't ever imagine doing anything to this level of excess.