Hmmmm... It would help if you said what speakers you're using, and what you're using for a source.
That said, I've never heard Frank's all-tube stuff, having made the leap directly from Omega to F-V/Transcendence. I find the sonic signature of the Omega and hybrid stuff to be remarkably similar. The hybrid stuff is smoother, very slightly warmer and darker, has better transparency and, well, is just incredibly listenable.
If your source is CD and you don't have one of Frank's DACs, that could possibly make the biggest improvement. I had an Omega DAC for a number of years and it completely changed my thinking about CDs. I now have an Ultra and it is a complete revelation. Probably the one piece of equipment I am least likely to part with.
If you primarily listen to vinyl, you may well be happiest with one of Frank's tube preamps. It would almost certainly be an upgrade from the Omega.