Martyn,
Orientation of the trimpot will simply change the direction of turn of the adjuster. One will be CW for increased bias; the other, CCW. No other effect. For consistency I do try to assemble them myself in the same orientation, but it has no effect on operation, just adjustment sense. With a DMM connected to the emitters of the output devices you can check bias of the output stage without difficulty.
It has no effect either on operation or sonics. Jump in, Sir, and trust in Providence!!
Cheers,
Hugh