Frank, I own one of your 4i pre-amps with the tranny upgrade, driving a small Sonographe amp which is not too shabby. I just had a small self powered subwoofer, with a Class D or switching power supply, hooked to my preamp with a 10 foot interconnect. Electrical line noise apparently causes a feedback from the subwoofer amp back to the preamp through the interconnect. This noise then goes back out to the main amp and is heard in the main speakers, as a distortion very similar to a really bad ground. Floating the power ground on either the main amp or sub makes no difference. I had a similar problem with some switching supply mono amps. Any line noise made a "burp" in one amp that went back to the pre and out to the other channel and to the sub (different one), in that case.
Now when I phone this problem in the techs think that I am nuts. But isn't this possible? I don't think that there are any blocking caps in the preamp that would stop the trash from getting back in the loop.