In general we can make these statements:
1) the connection between preamp and amp is one of low voltage and high load impedance. Thus, very little current is flowing between the two components and therefore, very little potential drop can occur across the cable.
For example, the output from a CD player is 2V, by redbook std. Assuming unity gain level setting on the preamp, we have 2V on the output of the preamp. The input impedance of an amp is say 20Kohms. So the current computes to be 0.1mA I believe.
2) the connection between amp and speaker is one of high voltage and low load impedance. Thus, high current is flowing between the two components and therefore, a greater potential drop can occur across the cable.
For example, assuming the amp has a gain of 25dB, our 2V input will become 35.5V at the output. Assume we have the classic 8ohm speaker. So the current computes to be 4.4A I believe.
It is this several orders of magnitude difference in current flow bewteen the two scenarios that leads us to want short speaker cable with longer ICs.
The issues of noise contaminating a low level signal in the IC can be addressed by shielding and using balanced lines. The classic example addressing this is the microphone feed in the recording studio.
It's this same argument that says we need large gauge speaker wire (14 ga., 12 ga. etc.). Note that running double runs parallels the resistance and thus, reduces it by half. What's the gauge of your typical IC? For the Belden 1505F it's 21 ga.
-- Bob