System tweaking is always a joy. There could be a number of things here.
1) Does the hard drive suck power from the bus?
2) Is hard drive plugged into hub?
3) What powers hub?
4) Are both drive and HAGUSB plugged into same hub?
Basically, you can have either power problems or timing issues with the hub. Audio works best when plugged directly into a host USB port, not an expansion hub. All it takes is one or two missing packets to cause a glitch or 'tic'. The hard drive likely has multiple buffers in the path, so it can be on the non-critical hub port.
jh
