I only sand the joints if needed to get a tight fit, first dry fit and clamp, address any joint issues, glue and clamp, router the overhang/squeeze out once dry and flat sand. In the past when I sanded prior to glue up I caused more issues or did not impact the end results. Getting the joints seated well and clamped timely will be the challenge on such a large speaker IMO. If that is done well as you can the minor imperfections can be addressed during the finishing process. I also suggest you completely dry fit everything with clamps, clamping blocks and a good clamping sequence, you will see the areas in the joints that might need sanding during this process. It will also help to build confidence on the amount of time it will take, I would suggest two friends to help in both dry fit and glue up, due to the size of the speaker. My apologies if this is information that you already know, but just in case. Just don’t rush it!
I am sure some forum members that have built the larger speakers might have better or different suggestions, this is just the way I have approached the few builds I have done. I hope this answers your question. If you have watched Peters videos you’re good to go.