Welcome. My own experience leads me to say do not drive yourself crazy over your room and its acoustic inadequacies. If your room was exceptionally small, then, yes, you'd have to think more carefully about speaker type and size. Fortunately, you don't have that issue. Its size alone will mitigate (in my experience) the fireplace, lack of symmetry, and abundance of glass. My current room is approximately 15' x 30' with 9' ceilings.
I'm including a picture so you can see the room's many acoustic sins. As you can see, it is asymmetrical, there is a big window behind the speakers, a glass-doored cabinet between the speakers (albeit somewhat recessed), a largish tv on the wall to the side of the right speaker, a small false wall behind the left, an open stairway, and nooks, crannies, and hard surfaces abound, yet the speakers do all the things good speakers in good environments are reputed to do. They image with scale, clarity, and detail; the soundstage is wide, high, and deep; they reveal all sorts of micro detail without ever sounding dry or clinical; the bass is full and rich without being exaggerated or boomy; the mids are mellifluous; the highs are clear and bright or sweet as the instrument or music calls for; and, more than anything, they sound like music, they move me as music should. They sound, in a word, if I may use such a non-descriptive adjective, quite literally, wonderful, in that they truly evoke a sense of wonder. It may be that, were I able to amend all the room's issues, my speakers would shine even more brightly (that's a lame metaphor, not a description of their actual sound). Maybe. However, I can tell you with absolute certainty, however glorious they might sound in an acoustically ideal environment, they sound beautiful in their current compromised setting. My previous speakers, Dynaudio Heritage Specials, a small stand-mount box speaker, in this same room, also sounded great. The man who built my amp also has his X5s in a considerably larger, asymmetrical, open-floor-plan room with very large floor to ceiling windows looking out on a spectacular mountain range, the room filled with the accoutrement of living (as one would expect in a living room), and he assures me his system also sounds great. My long-winded point in all this is to say, if you listen to the strictures of hardcore devotees of sound propagation and acoustic mitigation, you can drive yourself bonkers fretting over your room's supposed shortcomings, or even (let's give science its due) actual, measurable, shortcomings. Don't. Your room is beyond fine. It's even good, and will accommodate whatever speakers you eventually put in it. Fill the room with the stuff of living. I strongly believe, whether we're sitting attentively still or moving about the room otherwise engaged, the music should be where we live, among the things and people that make up our lives. Not everyone will agree with this. Regardless, Spatial speakers will sound excellent in your room, as will box speakers. As I said, I loved the Dynaudios in my room. I prefer the Spatials because they do everything the Dynaudios did with the addition of a level of scale and openness the Dynaudios couldn't achieve. In either case, my room proved to be no hindrance, and neither will yours.
