Yes, the NX-Tremes, especially with all top of the line components in the crossovers, and a pair of 3-6 driver OB subs are end game speakers.
I'd say the minimum room size would be 16'x18'x8' with 18'x20'x9' being better. I'm not sure what the dimensions of Danny's listening room are at home or what they were at the last Lone Star Audio Fest. Maybe he will chime in with specifics.
For depth, you need at least 3' from the front wall to the baffle of the subs, another foot or two from the front of the subs to the rear of the NX-Tremes, then however far you want to sit away from them (I like 8'-12' for OB speakers), and finally, however much room you want behind the listening position to the back wall. The deeper the room, the more space you can have behind the listening position which reduces undesirable back wall reflections. If you can get 3'-6' or more behind the listening position you can put bass traps in the corner and diffusion in the center like on the front wall. If you don't have much room behind the listening position, like my situation, plenty of absorption on the back wall reduces undesirable reflections.
For width, you want the speakers spaced a little closer together than you are sitting away from them, then add however much room you space the inside of the sub from the outside of the NX-Treme plus the width of the sub. Since the subs are OB, they can be placed fairly close to the wall. With this approach, the distance the listening position is from the speakers determines the minimum width of the room.
More space is better. The farther you can pull the speakers and subs into the room in both depth and width and the taller the ceiling, the larger the soundstage will be in all three dimensions.
Mike