Regarding running the Opus 21 direct to an amp; in the past, I was not a fan of doing this. While running direct had many sonic qualities I liked (particularly transparancy and detail), I felt that the overall presentation lacked in other areas that I strongly preferred, including soundstage, bass impact, dynamics, and depth. My preference was strongly in favor of using an active preamp. But recently, after having a dedicated AC line installed in my listening room, I tried running the Opus 21 direct again...and the improvements to bass impact and dynamics was significant. I still have a preference for using an active preamp, but the gap was closed by a good amount, and I can certainly see the appeal of using the Opus 21 in this way much more than I did before.
Also, system matching is also very important for the Opus 21. I've demoed it in a lot of systems, and in some (my own Blue Circle/Focus setup, Cary/Triangle, DNM/Rethm, etc) it has been wonderful, and in others (Talk/Onix, Audiovalve/Von Schweikert) it has been not so great. Haven't found the exact characteristics of a system that make it a good match, so trying-before-buying is important...
So...good AC (dedicated line, good power cord) and system synergy have a big impact on how the Opus 21 performs...