SET600 would be happier delivering lots of power to a low impedance load than the M225 would be. The SET600 has twice as many output mosfets, so twice the drive capability (and half the output impedance). The M225 can drive a 4 ohm load, but the SET600 can drive it easier.
That said, I'd guess that the M225 would probably work fine, but be aware that a 4 ohm 86db Magnepan is probably right at its limits in terms of difficult speaker loads. The M225's work stunningly, and continuously with no heat issues, on Frank's 4 ohm 86db Philharmonic's so I'd guess they'd be great with Magnepan's too.
Dan