Hi Bigsled, and welcome to AC!

I'll shine what light I know on the subject, but my disclaimer is that I'm sure the next guy will know more than me!

You can absolutely swap tube brands between the gain stages of the amp! Of course, this means do not have different tubes for the same stage - For instance if you have two 12au7's, one for left speaker, on for right, of course those need to be the same, and ideally a matched pair.
Regarding one tube stage adding warmth one tube stage adding high treble extension for example... it does and does not work that way. Let me try to explain - My theory would be: a stage of amplification can only amplify the signal that is given to it. For instance, if you have a tube stage that completely takes out all high frequencies beyond 10khz, you cannot add another tube down the line that is known for high frequency extension and expect it to give back that extension past 10khz, or what was lost up the chain. It cannot add to something that is no longer there, once those frequencies are gone (up the line) nothing can give them back (in an analog world), it will only "color" what is still in the signal path. So, it's really a balancing act. Each tube is
almost equally as important, as they all change the sound (some say rectifiers don't change the sound... but I would certainly disagree with that). But just know, if you have a tube that limits something early in the chain, you cannot give back what was taken away. You COULD for instance fool yourself into thinking you're getting back these things from other tubes/components down the line, but IMO it would only be in the form of distortion that you're leveling out your frequency response, or tonality to taste.
Not sure if that at all helps you in the start of your now neverending
tube story

