Oh, I've been wondering about this for loooong time. I tried a DBX 223 solely as a 1-way to feather the bottom from 20-50 hz and I think it's OK, but when I tried it as a 2-way, the high-pass made a midfi mess of things and I pretty much gave up on the idea of placing a "foreign" object between the preamp and the amp.
But maybe a passive line-level high-pass crossover has a better chance to be ok?! I have a pair of speakers that might improve if they don't have to handle the signal below around 100 hz.