I hope that you and yours are safe and well as we undergo another of life's stress tests of humanity. It has been many years since I actually possessed a "full size" audio system, primarily due to financial challenges which have abated a bit. Now I can at least begin to assemble a system again. The priorities are maximum sound quality, reliability and flexibility for a reasonable investment. Components can be new, used, modified or full DIY that provide substantial value (sound quality vs cost) for the long term. Sources will be primarily digital (CD, streaming, PC-based) with minimal electronics (SS or tube). Speakers can be floor-standing, stand-mounts (with or without a sub) and relatively sensitive (90db+) powered or passive. Primary room is 19' long, 12' wide, 9' high with plaster/lath & drywall walls. While I have minimal tools for full DIY (I built a Dynaco SCA80Q years ago), a close friend is a skilled woodworker.
That's about it.